1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE
N-Boc-4-Carbethoxy Piperidine
CAS: 142851-03-4
Molecular Formula: C13H23NO4
1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE - Names and Identifiers
1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE - Physico-chemical Properties
| Molecular Formula | C13H23NO4 |
| Molar Mass | 257.33 |
| Density | 1.046 g/mL at 25 °C |
| Boling Point | 120-135 °C/0.5 mmHg |
| Flash Point | >230°F |
| Solubility | Chloroform, Ethyl Acetate |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | Liquid |
| Color | Clear colorless to pale yellow |
| pKa | -2.23±0.40(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Refractive Index | n20/D 1.458 |
1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | R22 - Harmful if swallowed R37/38 - Irritating to respiratory system and skin. R41 - Risk of serious damage to eyes |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S39 - Wear eye / face protection. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Class | IRRITANT |
1-(TERT-BUTYL) 4-ETHYL TETRAHYDRO-1,4(2H)-PYRIDINEDICARBOXYLATE - Reference Information
| introduction | ethyl N-Boc-4-piperidine formate has an extremely light yellow or light yellow liquid appearance at normal temperature and pressure and can be used as an intermediate in organic synthesis. It is a commercial organic synthon, which has good solubility in common organic solvents such as ethyl acetate, dichloromethane, and chloroform, and poor solubility in water. |
| Use | Ethyl N-Boc-4-piperidinoate is a common organic synthesis intermediate. Its main use is to participate in the synthesis of drug molecules and biologically active molecules as a molecular skeleton. The ester group on the ring of ethyl N-Boc-4-piperidinoate can be converted into a series of active functional groups, such as hydroxyl, aldehyde, etc. The N-Boc group on the other side can easily remove Boc and release the secondary amine. In addition, the N-Boc can also reduce the Boc group to methyl group under the reduction of lithium tetrahydroaluminum, so as to obtain the corresponding Tertiary amine compounds. |
| synthesis method | aiming at the synthesis of ethyl N-Boc-4-piperidinoate, the conventional synthesis method is to obtain Boc-protected ethyl 4-piperidinoate by reacting with ditert-butyl dicarbonate starting from commercial ethyl 4-piperidinoate. There are literatures that the target product can be obtained by directly stirring the two reactions together, and there are also related literatures that the reaction process is iodized and acetonitrile is used as a solvent to obtain the target product in a high yield. |
Last Update：2024-04-09 20:52:54
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